After a major record label bidding war, Young Money Entertainment announced on August 31, 2009 that Minaj had been released a 360 deal with the label in which she retains and owns all of her 360 rights – including merchandising, sponsorships, endorsements, touring and publishing. In an interview with 95.8 Capital FM, Rihanna stated that after the two collaborated on "Raining Men" from her album Loud that the duo would be teaming up together for a possible second collaboration on Minaj's Pink Friday. Hip-hop rap artist and producer Kanye West was also confirmed for the album. On August 3, 2010 Minaj revealed on a Ustream.tv channel for her fans that the album's name would be Pink Friday, stating, “To carry on a great tradition of Black Friday, we are going to switch it up this year in honor of the Nicki Minaj album and call that day Pink Friday, and call my album Pink Friday!” Minaj released the artwork for her album cover on October 15, 2010.


Pink Friday was released on November 19, 2010 in both standard and deluxe versions. A buzz single, "Massive Attack", was released in April. In August, Minaj released "Your Love" as the first official single from her debut album. The single peaked at 14 on the Billboard Hot 100, 7 on the Hot R&B/Hip-Hop Songs chart and topped the Rap Songs chart. Minaj became the first female artist to be included on MTV's Annual Hottest MC List and the first female artist to top the chart unaccompanied since 2002. In October 2010, Minaj became the first artist to have seven songs on the Billboard Hot 100 chart simultaneously. Minaj released a joint single with The Black Eyed Peas front man, will.i.am titled, "Check It Out", which is Minaj's most successful single to date in Europe. "Right thru Me" was released September 24, 2010; the music video was released in late October. "Moment 4 Life" followed "Right thru Me" and was released as the fourth single. The track featured Canadian rapper Drake and was released on December 7, 2010, becoming a success on the Billboard Hot 100. The single peaked at number 5 on the Hot Rap Songs. The album gained a Platinum certification in the United States a month after the release.


On January 29, 2011, Minaj appeared on Saturday Night Live as the musical guest, performing "Right Thru Me" and "Moment 4 Life". On February 9, 2011, it was announced that Pink Friday had reached number one on the Billboard 200 in its eleventh week on the chart. It was hinted by Simon Cowell that Minaj would join the judging panel of the American version of the The X Factor. Starting in June 2011, Minaj will be supporting Pink Friday by serving as an opening act along with Jessie and the Toy Boys and Nervo on Britney Spears' sixth concert tour, the Femme Fatale Tour, in support of her seventh studio album, Femme Fatale. She also was featured on the official remix of Spears' track "Till The World Ends" along with Spears and singer Kesha, which charted at number 3 in the US in April 2011. "Super Bass" was released from Pink Friday in May 2011, the reception of the single was huge after the single charted within the top 10 in many of countries including; United Kingdom, United States, Australia, Canada and more. The song gained positive reviews from critics with some critics saying; "obvious hit", "memorable hooks", "infectious". Minaj will voice a character in the 3D animated film, Ice Age: Continental Drift, as an unknown character,. Minaj is also featured on French disc jockey David Guetta's 2011 album, Nothing but the Beat on "Where Them Girls At" and "Turn Me On". She will be featured alongside Madonna and M.I.A on an upcoming single from Madonna's twelfth studio album, for which a music video has been directed by Megaforce.


On November 22, 2011, Minaj announced via Twitter that her sophomore album, Pink Friday: Roman Reloaded, is currently in the works set to be released on Valentine's Day 2012. She later retweeted to one of her fans saying that she would release a teaser of the LP's first single on the week of December 6th-9th. The first single from the album, titled "Roman in Moscow," was released to iTunes and to the radio on December 2, 2011. The cover has a red background with the name Nicki Minaj crossed out and instead saying Roman in Moscow. On the top Minaj songs on iTunes, "Roman in Moscow" ranked number three.